Loss of ß-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation.

Mostafa, Dina; Yanagiya, Akiko; Georgiadou, Eleni; Wu, Yibo; Stylianides, Theodoros; Rutter, Guy A; Suzuki, Toru; Yamamoto, Tadashi

Mostafa, Dina; Yanagiya, Akiko; Georgiadou, Eleni; Wu, Yibo; Stylianides, Theodoros; Rutter, Guy A; Suzuki, Toru; Yamamoto, Tadashi.

Afiliação

Mostafa D; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Yanagiya A; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Georgiadou E; Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan.
Wu Y; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, UK.
Stylianides T; Laboratory for Next-Generation Proteomics, Riken Center of Integrative Medical Sciences, Yokohama, Japan.
Rutter GA; Centre of Innovative and Collaborative Construction Engineering, Loughborough University, Leicestershire, UK.
Suzuki T; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, UK.
Yamamoto T; Laboratory for Immunogenetics, Riken Center of Integrative Medical Sciences, Yokohama, Japan. toru.suzuki.ff@riken.jp.

Commun Biol ; 3(1): 476, 2020 08 28.

Article em En | MEDLINE | ID: mdl-32859966

Assuntos

Diabetes Mellitus Experimental/patologia; Células Secretoras de Insulina/patologia; Fatores de Transcrição/metabolismo; Animais; Contagem de Células; Diferenciação Celular/genética; Diabetes Mellitus Experimental/genética; Modelos Animais de Doenças; Glucose/toxicidade; Teste de Tolerância a Glucose; Insulina/metabolismo; Secreção de Insulina; Células Secretoras de Insulina/metabolismo; Lipídeos/toxicidade; Masculino; Camundongos Knockout; Modelos Biológicos; Obesidade/patologia; Fenótipo; Proteoma/metabolismo; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Transcriptoma/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Diabetes Mellitus Experimental / Células Secretoras de Insulina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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