Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes.

Staudt, Ryan P; Alvarado, John J; Emert-Sedlak, Lori A; Shi, Haibin; Shu, Sherry T; Wales, Thomas E; Engen, John R; Smithgall, Thomas E

Staudt, Ryan P; Alvarado, John J; Emert-Sedlak, Lori A; Shi, Haibin; Shu, Sherry T; Wales, Thomas E; Engen, John R; Smithgall, Thomas E.

Afiliação

Staudt RP; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Alvarado JJ; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Emert-Sedlak LA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Shi H; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Shu ST; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Wales TE; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
Engen JR; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, USA.
Smithgall TE; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address: tsmithga@pitt.edu.

J Biol Chem ; 295(44): 15158-15171, 2020 10 30.

Article em En | MEDLINE | ID: mdl-32862141

Assuntos

Fármacos Anti-HIV/farmacologia; HIV-1/enzimologia; Inibidores de Proteínas Quinases/farmacologia; Proteínas Quinases/metabolismo; Produtos do Gene nef do Vírus da Imunodeficiência Humana/metabolismo; Antígenos CD4/metabolismo; Cristalografia por Raios X; Regulação para Baixo; HIV-1/patogenicidade; Evasão da Resposta Imune; Complexo Principal de Histocompatibilidade; Proteínas de Membrana/metabolismo; Proteínas Quinases/efeitos dos fármacos; Transporte Proteico; Relação Estrutura-Atividade; Produtos do Gene nef do Vírus da Imunodeficiência Humana/química

Palavras-chave

AIDS; Btk; CD4; HIV-1 Nef; Hck; Itk; MHC-I; SH2 domain; SH3 domain; Src homology 2 domain (SH2 domain); Src homology 3 domain (SH3 domain); Src-family kinases; Tec-family kinases; bimolecular fluorescence complementation (BiFC); dimerization; endocytosis; human immunodeficiency virus (HIV); infectious disease; major histocompatibility complex (MHC); protein-protein interaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Quinases / HIV-1 / Fármacos Anti-HIV / Inibidores de Proteínas Quinases / Produtos do Gene nef do Vírus da Imunodeficiência Humana Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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