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Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).
Pan, Shulei; Zhou, Yangli; Wang, Qiusheng; Wang, Yanlin; Tian, Chenyu; Wang, Tianqi; Huang, Luyi; Nan, Jinshan; Li, Linli; Yang, Shengyong.
Afiliação
  • Pan S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Zhou Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Wang Q; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Wang Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Tian C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Wang T; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Huang L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Nan J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
  • Li L; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan, 610041, China. Electronic address: ysylilinli@sina.com.
  • Yang S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: yangsy@scu.edu.cn.
Eur J Med Chem ; 207: 112703, 2020 Dec 01.
Article em En | MEDLINE | ID: mdl-32871341
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Triptofano Oxigenase / Inibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenase Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Triptofano Oxigenase / Inibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenase Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article