Effect of photobiomodulation therapy on radiodermatitis in a mouse model: an experimental animal study.
Lasers Med Sci
; 36(4): 843-853, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-32876761
ABSTRACT
This study aimed to evaluate the effect of photobiomodulation (PBM) for prevention of radiodermatitis in an irradiated mouse model and compare the efficacy of PBM using 633- or 830-nm wavelengths. Irradiated mice were randomly distributed into three groups A (633 nm), B (830 nm), and C (without PBM). On post-irradiation days 7 and 21, we compared acute damage and recovery in treated skin samples to non-irradiated skin using H&E, Masson's trichrome, anti-CD45 and PCNA immunohistochemistry, and a TUNEL assay. Grade 3 radiodermatitis was evident only in group C. Compared with that in group C, the skin in groups A and B had significantly less epidermal hyperplasia, inflammatory cell infiltration, and thinner dermis on day 7 and less inflammatory cell infiltration, fewer apoptotic cells, and thinner dermis on day 21. However, there was no significant difference between groups A and B. This study indicates PBM could prevent severe radiodermatitis by reducing epidermal and dermal damage, inflammation, and apoptosis. There was no difference in PBM efficacy between the 633- and 830-nm wavelengths.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Radiodermite
/
Terapia com Luz de Baixa Intensidade
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article