ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.

Rainey, Michael D; Bennett, Declan; O'Dea, Rachel; Zanchetta, Melania E; Voisin, Muriel; Seoighe, Cathal; Santocanale, Corrado

Rainey, Michael D; Bennett, Declan; O'Dea, Rachel; Zanchetta, Melania E; Voisin, Muriel; Seoighe, Cathal; Santocanale, Corrado.

Afiliação

Rainey MD; Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway H91W2TY, Ireland.
Bennett D; School of Mathematics, Statistics, and Applied Mathematics, National University of Ireland Galway, Galway H91TK33, Ireland.
O'Dea R; Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway H91W2TY, Ireland.
Zanchetta ME; Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway H91W2TY, Ireland.
Voisin M; Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway H91W2TY, Ireland.
Seoighe C; School of Mathematics, Statistics, and Applied Mathematics, National University of Ireland Galway, Galway H91TK33, Ireland.
Santocanale C; Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway H91W2TY, Ireland. Electronic address: corrado.santocanale@nuigalway.ie.

Cell Rep ; 32(9): 108096, 2020 09 01.

Article em En | MEDLINE | ID: mdl-32877678

Assuntos

Proteínas Mutadas de Ataxia Telangiectasia/metabolismo; Proteínas de Ciclo Celular/antagonistas & inibidores; Replicação do DNA/fisiologia; DNA/biossíntese; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Antígenos de Superfície/genética; Antígenos de Superfície/metabolismo; Proteínas Mutadas de Ataxia Telangiectasia/antagonistas & inibidores; Proteínas Mutadas de Ataxia Telangiectasia/genética; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Linhagem Celular; DNA/genética; Células HEK293; Células HeLa; Humanos; Mitose/fisiologia; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo

Palavras-chave

CRISPR-Cas9 screen; DNA replication; ETAA1; RIF1; cell cycle; checkpoint; functional genomics; kinase inhibitor; replication origins; replication stress

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Proteínas Serina-Treonina Quinases / Proteínas de Ciclo Celular / Replicação do DNA / Proteínas Mutadas de Ataxia Telangiectasia Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google