The central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability.

Guo, Wenting; Sun, Bo; Estillore, John Paul; Wang, Ruiwu; Chen, S R Wayne

Guo, Wenting; Sun, Bo; Estillore, John Paul; Wang, Ruiwu; Chen, S R Wayne.

Afiliação

Guo W; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Sun B; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Medical School, Kunming University of Science
Estillore JP; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Wang R; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Chen SRW; Department of Physiology and Pharmacology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Biochemistry and Molecular Biology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. Electronic address: swchen@ucalgary.ca.

J Biol Chem ; 295(46): 15622-15635, 2020 11 13.

Article em En | MEDLINE | ID: mdl-32878990

Assuntos

Miocárdio/metabolismo; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo; Trifosfato de Adenosina/farmacologia; Sítios de Ligação; Cafeína/farmacologia; Cálcio/metabolismo; Sinalização do Cálcio/efeitos dos fármacos; Células HEK293; Humanos; Magnésio/química; Magnésio/metabolismo; Simulação de Dinâmica Molecular; Mutagênese Sítio-Dirigida; Ligação Proteica/efeitos dos fármacos; Estabilidade Proteica; Estrutura Terciária de Proteína; Rianodina/química; Rianodina/metabolismo; Canal de Liberação de Cálcio do Receptor de Rianodina/química; Canal de Liberação de Cálcio do Receptor de Rianodina/genética

Palavras-chave

Ca2+ activation; Mg2+ inhibition; basal activity; calcium; calcium channel; calcium imaging; calcium intracellular release; inositol trisphosphate receptor (InsP3R); ryanodine binding; ryanodine receptor; sarcoplasmic reticulum (SR)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canal de Liberação de Cálcio do Receptor de Rianodina / Miocárdio Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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