Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.

Shao, Zhengping; Lee, Brian J; Rouleau-Turcotte, Élise; Langelier, Marie-France; Lin, Xiaohui; Estes, Verna M; Pascal, John M; Zha, Shan

Shao, Zhengping; Lee, Brian J; Rouleau-Turcotte, Élise; Langelier, Marie-France; Lin, Xiaohui; Estes, Verna M; Pascal, John M; Zha, Shan.

Afiliação

Shao Z; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York City, NY 10032, USA.
Lee BJ; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York City, NY 10032, USA.
Rouleau-Turcotte É; Université de Montréal, Biochemistry and Molecular Medicine, Montréal, Québec H3T 1J4, Canada.
Langelier MF; Université de Montréal, Biochemistry and Molecular Medicine, Montréal, Québec H3T 1J4, Canada.
Lin X; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York City, NY 10032, USA.
Estes VM; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York City, NY 10032, USA.
Pascal JM; Université de Montréal, Biochemistry and Molecular Medicine, Montréal, Québec H3T 1J4, Canada.
Zha S; Institute for Cancer Genetics, Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York City, NY 10032, USA.

Nucleic Acids Res ; 48(17): 9694-9709, 2020 09 25.

Article em En | MEDLINE | ID: mdl-32890402

Assuntos

Dano ao DNA; Reparo do DNA/efeitos dos fármacos; Poli(ADP-Ribose) Polimerase-1/genética; Poli(ADP-Ribose) Polimerase-1/metabolismo; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Sítios de Ligação; Domínio Catalítico; Linhagem Celular Tumoral; Reparo do DNA/fisiologia; Transferência Ressonante de Energia de Fluorescência; Proteínas de Fluorescência Verde/genética; Proteínas de Fluorescência Verde/metabolismo; Humanos; Indazóis/farmacologia; Cinética; Imagem Molecular; NAD/metabolismo; Piperidinas/farmacologia; Poli(ADP-Ribose) Polimerases/genética; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Proteína 1 Complementadora Cruzada de Reparo de Raio-X/genética; Proteína 1 Complementadora Cruzada de Reparo de Raio-X/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Reparo do DNA / Inibidores de Poli(ADP-Ribose) Polimerases / Poli(ADP-Ribose) Polimerase-1 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google