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SARS-CoV-2 and the safety margins of cell-based biological medicinal products.
Modrof, Jens; Kerschbaum, Astrid; Farcet, Maria R; Niemeyer, Daniela; Corman, Victor M; Kreil, Thomas R.
Afiliação
  • Modrof J; Global Pathogen Safety, Baxter AG (part of Takeda), Benatzkygasse 2-6, 1221, Vienna, Austria.
  • Kerschbaum A; Global Pathogen Safety, Baxter AG (part of Takeda), Benatzkygasse 2-6, 1221, Vienna, Austria.
  • Farcet MR; Global Pathogen Safety, Baxter AG (part of Takeda), Benatzkygasse 2-6, 1221, Vienna, Austria.
  • Niemeyer D; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and German Centre for Infection Research, Berlin, Germany.
  • Corman VM; Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and German Centre for Infection Research, Berlin, Germany.
  • Kreil TR; Global Pathogen Safety, Baxter AG (part of Takeda), Benatzkygasse 2-6, 1221, Vienna, Austria. Electronic address: thomas.kreil@takeda.com.
Biologicals ; 68: 122-124, 2020 Nov.
Article em En | MEDLINE | ID: mdl-32891497
ABSTRACT
With the pandemic emergence of SARS-CoV-2, the exposure of cell substrates used for manufacturing of medicines has become a possibility. Cell lines used in biomanufacturing were thus evaluated for their SARS-CoV-2 susceptibility, and the detection of SARS-CoV-2 in culture supernatants by routine adventitious virus testing of fermenter harvest tested.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Replicação Viral / Infecções por Coronavirus / Betacoronavirus Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Replicação Viral / Infecções por Coronavirus / Betacoronavirus Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article