Obesity, COVID-19 and innate immunometabolism.
Br J Nutr
; 125(6): 628-632, 2021 03 28.
Article
em En
| MEDLINE
| ID: mdl-32892755
ABSTRACT
As COVID-19 continues to spread worldwide, severe disease and mortality have been observed in obese patients. We discuss how obesity and obesity-associated factors such as 'meta-flammation', dietary fat intake and paradoxical suppression of the innate immune response within the pulmonary compartment may be crucial determinants in the host response to a novel viral pathogen. Modulation of immune cell bioenergetics and metabolic potential plays a central role in the innate immune response to infection, and as we strive to combat this new global health threat, immunometabolism of the innate immune system warrants attention.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
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COVID-19
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Sistema Imunitário
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Obesidade
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article