tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast.

Tavares, Joana F; Davis, Nick K; Poim, Ana; Reis, Andreia; Kellner, Stefanie; Sousa, Inês; Soares, Ana R; Moura, Gabriela M R; Dedon, Peter C; Santos, Manuel

Tavares, Joana F; Davis, Nick K; Poim, Ana; Reis, Andreia; Kellner, Stefanie; Sousa, Inês; Soares, Ana R; Moura, Gabriela M R; Dedon, Peter C; Santos, Manuel.

Afiliação

Tavares JF; Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Davis NK; Department of Biological Engineering, Massachusetts Institute of Technology - MIT, Cambridge, US.
Poim A; Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Reis A; Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Kellner S; Department of Biological Engineering, Massachusetts Institute of Technology - MIT, Cambridge, US.
Sousa I; Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Soares AR; Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Moura GMR; Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.
Dedon PC; Department of Biological Engineering, Massachusetts Institute of Technology - MIT, Cambridge, US.
Santos M; Singapore-MIT Alliance for Research and Technology, Campus for Research Excellence and Technical Enterprise - CREATE, Singapore.

RNA Biol ; 18(4): 563-575, 2021 04.

Article em En | MEDLINE | ID: mdl-32893724

Assuntos

Enzimas/genética; Agregados Proteicos/genética; Biossíntese de Proteínas/genética; RNA de Transferência/metabolismo; Saccharomyces cerevisiae; Códon/genética; Mutação; Organismos Geneticamente Modificados; Proteostase/genética; Processamento Pós-Transcricional do RNA/genética; RNA de Transferência/genética; Saccharomyces cerevisiae/genética; Saccharomyces cerevisiae/metabolismo

Palavras-chave

(5-10) tRNA modifying enzymes; protein aggregation; proteome; tRNA; yeast

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / Biossíntese de Proteínas / RNA de Transferência / Enzimas / Agregados Proteicos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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