Toxicosis with grapes or raisins causing acute kidney injury and neurological signs in dogs.
J Vet Intern Med
; 34(5): 1957-1966, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32893916
ABSTRACT
BACKGROUND:
The ingestion of grapes or raisins has been reported to cause acute kidney injury (AKI) in dogs, with a clinical picture dominated by early gastrointestinal signs and rapidly developing uremia. Ataxia is mentioned in a few reports, but not further characterized.OBJECTIVES:
To evaluate the clinical, laboratory, and pathological features of dogs diagnosed with grape or raisin toxicosis (GRT) with emphasis on renal and neurological manifestations, compared to a control group of dogs with AKI from other causes. ANIMALS Fifteen client-owned dogs with GRT and 74 control dogs.METHODS:
Retrospective study over 17 months.RESULTS:
All dogs with GRT were presented with severe AKI (grade 4, n = 5; grade 5, n = 10). Eleven dogs (73%) had marked forebrain, cerebellar, or vestibular signs. These manifestations dominated the clinical picture in some dogs, but were not associated with the severity of azotemia or the presence of systemic hypertension. Eight dogs (53%) survived, and 5 dogs experienced a complete neurological recovery. Causes of death were unrelated to the neurological manifestations. Neuropathological examination of 4 dogs did not identify any structural central nervous system abnormality. Only 2 control dogs (3%) displayed neurological signs with seizures unrelated to the AKI; 42 control dogs (57%) survived. CONCLUSIONS AND CLINICAL IMPORTANCE Severe forebrain, cerebellar, or vestibular signs may be an important feature of GRT and dominate the early clinical picture. The described features suggest a reversible functional brain injury specific to GRT and unrelated to uremia.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vitis
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Doenças do Cão
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Azotemia
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Injúria Renal Aguda
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article