Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications.

Ong, Wei-Yi; Go, Mei-Lin; Wang, De-Yun; Cheah, Irwin Kee-Mun; Halliwell, Barry

Ong, Wei-Yi; Go, Mei-Lin; Wang, De-Yun; Cheah, Irwin Kee-Mun; Halliwell, Barry.

Afiliação

Ong WY; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119260, Singapore. antongwy@nus.edu.sg.
Go ML; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore, 119260, Singapore. antongwy@nus.edu.sg.
Wang DY; Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 119260, Singapore.
Cheah IK; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119260, Singapore.
Halliwell B; Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore, 119260, Singapore.

Mol Neurobiol ; 58(1): 106-117, 2021 Jan.

Article em En | MEDLINE | ID: mdl-32897518

Assuntos

Antimaláricos/uso terapêutico; Tratamento Farmacológico da COVID-19; COVID-19/complicações; Doenças do Sistema Nervoso/tratamento farmacológico; Doenças do Sistema Nervoso/etiologia; SARS-CoV-2; Animais; Antimaláricos/metabolismo; Barreira Hematoencefálica/efeitos dos fármacos; Barreira Hematoencefálica/metabolismo; COVID-19/metabolismo; Humanos; Doenças do Sistema Nervoso/metabolismo; Resultado do Tratamento

Palavras-chave

Aminoacridine; Antimalarials; Aortic body; Arachidonic acid; Brain endothelial cells; COVID; COVID-19; Carotid body; Chloroquine; Coronavirus; Cytosolic phospholipase A2; DMT1; Eicosanoids; Free radical damage; Glossopharyngeal nerve; Hippocampus; Hydroxychloroquine; Inflammation; Iron transport; Lysosomes; Microcirculation; Microglia; Microvessels; Neuroinflammation; Nucleus of the tractus solitarius; Oxidative stress; Quinacrine; Respiratory centre; SARS; SARS-CoV-2; Secretory phospholipase A2; Statins; Stroke; TNF-α; Vagus nerve; Vascular dementia; cPLA2; sPLA2 IID

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 / Tratamento Farmacológico da COVID-19 / Doenças do Sistema Nervoso / Antimaláricos Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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