Cataract-Associated New Mutants S175G/H181Q of ß&#914;2-Crystallin and P24S/S31G of Î³D-Crystallin Are Involved in Protein Aggregation by Structural Changes.

Song, In-Kang; Na, Seungjin; Paek, Eunok; Lee, Kong-Joo

Cataract-Associated New Mutants S175G/H181Q of ßΒ2-Crystallin and P24S/S31G of Î³D-Crystallin Are Involved in Protein Aggregation by Structural Changes.

Song, In-Kang; Na, Seungjin; Paek, Eunok; Lee, Kong-Joo.

Afiliação

Song IK; Department of Pharmacy, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
Na S; Department of Computer Science, Hanyang University, Seoul 04763, Korea.
Paek E; Department of Computer Science, Hanyang University, Seoul 04763, Korea.
Lee KJ; Department of Pharmacy, College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.

Int J Mol Sci ; 21(18)2020 Sep 05.

Article em En | MEDLINE | ID: mdl-32899552

Assuntos

Catarata/genética; Cadeia B de beta-Cristalina/genética; gama-Cristalinas/genética; Adolescente; Adulto; Idoso; Pré-Escolar; Humanos; Recém-Nascido; Cristalino/metabolismo; Mutação/genética; Agregados Proteicos/genética; Estabilidade Proteica; Proteômica/métodos; Cadeia B de beta-Cristalina/metabolismo; gama-Cristalinas/metabolismo

Palavras-chave

cataract-associated mutants; hydrogen-deuterium exchange-MS; post translational modification; protein aggregation; proteomics dataset; stability change; structural change; ßΒ2-crystallin; Î³D-crystallin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catarata / Cadeia B de beta-Cristalina / Gama-Cristalinas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child, preschool / Humans / Newborn Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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