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APRIL-producing eosinophils are involved in gastric MALT lymphomagenesis induced by Helicobacter sp infection.
Blosse, Alice; Peru, Sara; Levy, Michael; Marteyn, Benoit; Floch, Pauline; Sifré, Elodie; Giese, Alban; Prochazkova-Carlotti, Martine; Azzi Martin, Lamia; Dubus, Pierre; Mégraud, Francis; Ruskone Fournestraux, Agnès; Fabiani, Bettina; Copie Bergman, Christiane; Robe, Cyrielle; Hahne, Michael; Huard, Bertrand; Lehours, Philippe.
Afiliação
  • Blosse A; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Peru S; CHU de Bordeaux, 33000, Bordeaux, France.
  • Levy M; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Marteyn B; EC2M3: Department of Academic Research (EA7375), Université Paris Est Créteil (UPEC) - Val de Marne, 94000, Créteil, France.
  • Floch P; Department of Gastroenterology, Henri Mondor Hospital, APHP, 94000, Créteil, France.
  • Sifré E; Institut Pasteur, Unité de Pathogénie Microbienne Moléculaire, 28 rue du Dr Roux, 75724, Paris Cedex 15, France.
  • Giese A; INSERM Unité 1202, 28 rue du Dr Roux, 75724, Paris Cedex 15, France.
  • Prochazkova-Carlotti M; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Azzi Martin L; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Dubus P; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Mégraud F; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Ruskone Fournestraux A; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Fabiani B; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Copie Bergman C; CHU de Bordeaux, 33000, Bordeaux, France.
  • Robe C; Univ. Bordeaux, INSERM, BaRITOn, U1053, 33000, Bordeaux, France.
  • Hahne M; French National Reference Center for Campylobacters and Helicobacters, Hôpital Pellegrin, 33076, Bordeaux, France.
  • Huard B; CHU de Bordeaux, 33000, Bordeaux, France.
  • Lehours P; Department of Gastroenterology, Groupe d'Etude des Lymphomes Digestifs (GELD), Hôpital Saint Antoine, AP-HP, 75012, Paris, France.
Sci Rep ; 10(1): 14858, 2020 09 09.
Article em En | MEDLINE | ID: mdl-32908188
The roles of the inflammatory response and production of a proliferation-inducing ligand (APRIL) cytokine in gastric mucosa-associated lymphoid tissue (MALT) lymphomagenesis induced by Helicobacter species infection are not clearly understood. We characterized the gastric mucosal inflammatory response associated with gastric MALT lymphoma (GML) and identified APRIL-producing cells in two model systems: an APRIL transgenic mouse model of GML induced by Helicobacter infection (Tg-hAPRIL) and human gastric biopsy samples from Helicobacter pylori-infected GML patients. In the mouse model, polarization of T helper 1 (tbet), T helper 2 (gata3), and regulatory T cell (foxp3) responses was evaluated by quantitative PCR. In humans, a significant increase in april gene expression was observed in GML compared to gastritis. APRIL-producing cells were eosinophilic polynuclear cells located within lymphoid infiltrates, and tumoral B lymphocytes were targeted by APRIL. Together, the results of this study demonstrate that the Treg-balanced inflammatory environment is important for gastric lymphomagenesis induced by Helicobacter species, and suggest the pro-tumorigenic potential of APRIL-producing eosinophils.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T / Infecções por Helicobacter / Linfoma de Zona Marginal Tipo Células B / Eosinófilos / Membro 13 da Superfamília de Ligantes de Fatores de Necrose Tumoral Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Linfócitos T / Infecções por Helicobacter / Linfoma de Zona Marginal Tipo Células B / Eosinófilos / Membro 13 da Superfamília de Ligantes de Fatores de Necrose Tumoral Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article