The Measurement of Insulin Clearance.
Diabetes Care
; 43(9): 2296-2302, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32910777
ABSTRACT
Insulin clearance has recently been highlighted as a fundamental aspect of glucose metabolism, as it has been hypothesized that its impairment could be related to an increased risk of developing type 2 diabetes. This review focuses on methods used to calculate insulin clearance from the early surrogate indices employing C-peptideinsulin molar ratio, to direct measurement methods used in animal models, to modeling-based techniques to estimate the components of insulin clearance (hepatic versus extrahepatic). The methods are explored and interpreted by critically highlighting advantages and limitations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Técnicas de Diagnóstico Endócrino
/
Insulina
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article