Contribution of spathulenol to the anti-nociceptive effects of Psidium guineense.
Nutr Neurosci
; 25(4): 812-822, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-32912110
ABSTRACT
Objectives:
Araçá-verdadeiro is the popular name of Psidium guineense (Myrtaceae), whose fruits and leaves are used in Brazilian folk medicine for treatment of inflammation and pain. The focus of the present research was an investigation of the anti-nociceptive, and anti-inflammatory effects of the essential oil from P. guineense (EOPG) leaves, and of spathulenol. The anxiolytic and antidepressive effects associated with chronic pain were also investigated in models of acute or persistent nociception or/and inflammatory pain.Methods andResults:
Oral treatment with EOPG (10-100â mg/kg) or spathulenol (10â mg/kg) significantly inhibited formalin-induced nociceptive responses, both sensitivity to cold and edema. Oral treatment with EOPG (10â mg/kg) and spathulenol (10â mg/kg) did not reduce locomotor activity (open field test). Local administration of spathulenol (1000â µg/paw) significantly prevented formalin-induced nociceptive sensitivity to cold and paw edema, and carrageenan-induced mechanical hyperalgesia, paw edema and sensitivity to cold. In the Freund's complete adjuvant (CFA) model, oral treatment with EOPG (10â mg/kg) or spathulenol (10â mg/kg) for 21 days significantly inhibited all analyzed parameters. The percentage maximal inhibition by spathulenol was 76.00% (mechanical hyperalgesia), 71.90% (cold response), 85.00% (edema), 77.16% (myeloperoxidase activity), 97.72% (time in the closed arms in the elevated plus maze), and 49.00% (immobility time in the tail suspension test), in the CFA model. Models employed male Swiss mice, except for the CFA test, which employed C57bL6 male mice (n=6 /group).Conclusion:
This study demonstrates that EOPG is an anti-nociceptive and anti-hyperalgesic agent, in acute and continuous treatment, and an anxiolytic and antidepressive agent when tested with the chronic pain experimental state.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Psidium
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article