Design, synthesis and biological evaluation of 4-aryl-5-aminoalkyl-thiazole-2-amines derivatives as ROCK II inhibitors.
Bioorg Med Chem
; 28(19): 115683, 2020 10 01.
Article
em En
| MEDLINE
| ID: mdl-32912437
ABSTRACT
A series of 4-aryl-5-aminoalkyl-thiazole-2-amines were designed and synthesized, and their inhibitory activity on ROCK II was screened by enzyme-linked immunosorbent assay (ELISA). The results showed that 4-aryl-5-aminomethyl-thiazole-2-amines derivatives had certain ROCK II inhibitory activities. Compound 10l showed ROCK II inhibitory activity with IC50 value of 20 nM.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tiazóis
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Desenho de Fármacos
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Inibidores de Proteínas Quinases
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Quinases Associadas a rho
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Aminas
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article