Point-activated ESR1Y541S has a dramatic effect on the development of sexually dimorphic organs.
Genes Dev
; 34(19-20): 1304-1309, 2020 10 01.
Article
em En
| MEDLINE
| ID: mdl-32912899
Mutations in the estrogen receptor α (ERα) occur in endocrine-resistant metastatic breast cancer. However, a major gap persists with the lack of genetically tractable immune competent mouse models to study disease. Hence, we developed a Cre-inducible murine model expressing a point-activated ESR1Y541S (ESR1Y537S in humans) driven by its endogenous promoter. Germline expression of mutant ESR1Y541S reveals dramatic developmental defects in the reproductive organs, mammary glands, and bones of the mice. These observations provide critical insights into the tissue-specific roles of ERα during development and highlights the potential use of our model in further developmental and cancer studies.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptor alfa de Estrogênio
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Crescimento e Desenvolvimento
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article