Solid-State Radical C-H Trifluoromethylation Reactions Using Ball Milling and Piezoelectric Materials.
Angew Chem Int Ed Engl
; 59(50): 22570-22576, 2020 12 07.
Article
em En
| MEDLINE
| ID: mdl-32914933
ABSTRACT
The application of piezoelectricity for the generation of trifluoromethyl (CF3 ) radicals is reported together with the development of a method for the mechanochemical C-H trifluoromethylation of aromatic compounds. As compared to conventional solution-based approaches, this mechanoredox C-H trifluoromethylation enables cleaner and more sustainable access to a wide range of trifluoromethylated N-heterocycles and peptides, which are important structural motifs in modern drug discovery. This study thus represents an important milestone for future applications of mechanoredox systems to medicinal and pharmaceutical science.
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MEDLINE
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En
Ano de publicação:
2020
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Article