Mother's Own Milk Biomarkers Predict Coming to Volume in Pump-Dependent Mothers of Preterm Infants.
J Pediatr
; 228: 44-52.e3, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32916143
ABSTRACT
OBJECTIVE:
To assess serial secretory activation biomarker concentrations (sodium [Na], potassium [K], NaK, protein, lactose, and citrate) in mother's own milk (MOM) from breast pump-dependent mothers of preterm infants to determine associations with coming to volume (CTV), defined as producing at least 500 mL/day MOM by day 14 postpartum. STUDYDESIGN:
We collected serial MOM samples and pumped MOM volume data for 14 days postpartum in mothers who delivered at <33 weeks of gestation. Regression models and the Mann-Whitney U test were used to evaluate associations.RESULTS:
Among 40 mothers, 39 (mean gestational age, 28.8 weeks; 67% overweight/obese; 59% nonwhite) had paired MOM volume and biomarker data; 33% achieved CTV between postpartum days 6 and 14. In univariate models, MOM Na on postpartum day 5 and NaK on days 3 and 5 were associated with CTV. Mothers achieving CTV were more likely to have postpartum NaK ≤1 on day 3 (75% vs 25%; P = .06) and ≤0.8 on day 5 (69% vs 10%; P < .01). In a multivariable regression model, day 5 NaK (1 unit decrease in NaK OR, 18.7; 95% CI, 1.13-311.41; P = .049) and maternal prepregnancy body mass index (BMI) (1 unit increase in BMI OR, 0.88; 95% CI, 0.78-0.99; P = .04) were associated with CTV between postpartum days 6 and 14.CONCLUSIONS:
Secretory activation and CTV were compromised in breast pump-dependent mothers with preterm delivery. CTV was predicted by MOM Na level and NaK. These biomarkers have potential as objective point-of-care measures to detect potentially modifiable lactation problems in a high-risk population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aleitamento Materno
/
Recém-Nascido de muito Baixo Peso
/
Extração de Leite
/
Leite Humano
/
Mães
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article