Your browser doesn't support javascript.
loading
Susceptibility of Pseudomonas aeruginosa veterinary isolates to Pbunavirus PB1-like phages.
Fujiki, Jumpei; Furusawa, Takaaki; Munby, Montgomery; Kawaguchi, Chika; Matsuda, Yumie; Shiokura, Yusei; Nakamura, Keisuke; Nakamura, Tomohiro; Sasaki, Michihito; Usui, Masaru; Iwasaki, Tomohito; Gondaira, Satoshi; Higuchi, Hidetoshi; Sawa, Hirofumi; Tamura, Yutaka; Iwano, Hidetomo.
Afiliação
  • Fujiki J; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Furusawa T; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Munby M; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Kawaguchi C; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Matsuda Y; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Shiokura Y; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Nakamura K; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Nakamura T; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Sasaki M; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.
  • Usui M; Laboratory of Food Microbiology and Food Safety, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Iwasaki T; Department of Food Science and Human Wellness, College of Agriculture, Food and Environment Science, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Gondaira S; Laboratory of Veterinary Hygiene, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Higuchi H; Laboratory of Veterinary Hygiene, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
  • Sawa H; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.
  • Tamura Y; International Collaboration Unit, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan.
  • Iwano H; Global Virus Network, Baltimore, Maryland.
Microbiol Immunol ; 64(11): 778-782, 2020 Nov.
Article em En | MEDLINE | ID: mdl-32918505
ABSTRACT
In recent years, antimicrobial-resistant Pseudomonas aeruginosa strains have increased in the veterinary field. Therefore, phage therapy has received significant attention as an approach for overcoming antimicrobial resistance. In this context, we isolated and characterized four Pseudomonas bacteriophages. Phylogenetic analysis showed that the isolated phages are novel Myoviridae Pbunavirus PB1-like phages with ØR12 belonging to a different clade compared with the other three. These phages had distinct lytic activity against 22 P. aeruginosa veterinary isolates. The phage cocktail composed from the PB1-like phages clearly inhibited the occurrence of the phage-resistant variant, suggesting that these phages could be useful in phage therapy.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Bacteriófagos / Myoviridae Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Bacteriófagos / Myoviridae Idioma: En Ano de publicação: 2020 Tipo de documento: Article