Immunopathology of Hyperinflammation in COVID-19.
Am J Pathol
; 191(1): 4-17, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32919977
ABSTRACT
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented public health crisis worldwide. Recent studies indicate that a hyperinflammatory syndrome induced by SARS-CoV-2 contributes to disease severity and mortality in COVID-19. In this review, an overview of the pathophysiology underlying the hyperinflammatory syndrome in severe COVID-19 is provided. The current evidence suggests that the hyperinflammatory syndrome results from a dysregulated host innate immune response. The gross and microscopic pathologic findings as well as the alterations in the cytokine milieu, macrophages/monocytes, natural killer cells, T cells, and neutrophils in severe COVID-19 are summarized. The data highlighted include the potential therapeutic approaches undergoing investigation to modulate the immune response and abrogate lung injury in severe COVID-19.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Resposta Inflamatória Sistêmica
/
Síndrome da Liberação de Citocina
/
COVID-19
/
Sistema Imunitário
/
Inflamação
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article