The importance of virion-incorporated cellular RNA-Binding Proteins in viral particle assembly and infectivity.
Semin Cell Dev Biol
; 111: 108-118, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-32921578
ABSTRACT
RNA is a central molecule in RNA virus biology due to its dual function as messenger and genome. However, the small number of proteins encoded by viral genomes is insufficient to enable virus infection. Hence, viruses hijack cellular RNA-binding proteins (RBPs) to aid replication and spread. In this review we discuss the 'knowns' and 'unknowns' regarding the contribution of host RBPs to the formation of viral particles and the initial steps of infection in the newly infected cell. Through comparison of the virion proteomes of ten different human RNA viruses, we confirm that a pool of cellular RBPs are typically incorporated into viral particles. We describe here illustrative examples supporting the important functions of these RBPs in viral particle formation and infectivity and we propose that the role of host RBPs in these steps can be broader than previously anticipated. Understanding how cellular RBPs regulate virus infection can lead to the discovery of novel therapeutic targets against viruses.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
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Vírion
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Vírus
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Viroses
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RNA Mensageiro
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RNA Viral
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Proteínas de Ligação a RNA
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article