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Preferential infiltration of macrophages during early stages of insulitis in diabetes-prone BB rats.
Lee, K U; Kim, M K; Amano, K; Pak, C Y; Jaworski, M A; Mehta, J G; Yoon, J W.
Afiliação
  • Lee KU; Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.
Diabetes ; 37(8): 1053-8, 1988 Aug.
Article em En | MEDLINE | ID: mdl-3292325
The subpopulation of lymphoid cells at the different stages of insulitis in BB rats was determined by immunohistochemical techniques with various monoclonal antibodies, including the recently developed OX41, which distinguishes macrophages from T-lymphocytes, OX19 for pan-T-lymphocytes, W3/25 for both helper T-lymphocytes and macrophages, OX8 for cytotoxic T-lymphocytes and natural killer cells, and OX12 for B-lymphocytes. The major population of infiltrated cells found during the early stages of insulitis appeared to be macrophages. This preceded invasion by a mixed population of cells, including both T- and B-lymphocytes and/or natural killer cells. The preferential infiltration of macrophages during the early stages of insulitis strongly suggested that there might be an initial change in the target beta-cells that precedes their immune destruction, although the amplification of immune response by activated T-lymphocytes and natural killer cells at a later stage seemed to be required for the clinical expression of the disease.
Assuntos
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Base de dados: MEDLINE Assunto principal: Linfócitos T / Ilhotas Pancreáticas / Macrófagos Limite: Animals Idioma: En Ano de publicação: 1988 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Linfócitos T / Ilhotas Pancreáticas / Macrófagos Limite: Animals Idioma: En Ano de publicação: 1988 Tipo de documento: Article