Challenges and Opportunities of Genomic Approaches in Therapeutics Development.
Methods Mol Biol
; 2194: 107-126, 2021.
Article
em En
| MEDLINE
| ID: mdl-32926364
ABSTRACT
The magnitude of all therapeutic responses is significantly determined by genome structure, variation, and functional interactions. This determination occurs at many levels which are discussed in the current review. Well-established examples of structural variation between individuals are known to dictate an individual's response to numerous drugs, as clearly illustrated by warfarin. The exponential rate of genomic-based interrogation is coupled with an expanding repertoire of genomic technologies and applications. This is leading to an ever more sophisticated appreciation of how structural variation, regulation of transcription and genomic structure, both individually and collectively, define cell therapeutic responses.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Farmacogenética
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Genoma
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Perfilação da Expressão Gênica
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Genômica
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Estudo de Associação Genômica Ampla
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Pesquisa Translacional Biomédica
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Transcriptoma
Limite:
Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article