Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production.

Patten, David A; McGuirk, Shawn; Anilkumar, Ujval; Antoun, Ghadi; Gandhi, Karan; Parmar, Gaganvir; Iqbal, Mohamed Ariff; Wong, Jacob; Richardson, Richard B; St-Pierre, Julie; Slack, Ruth S; Harper, Mary-Ellen

Patten, David A; McGuirk, Shawn; Anilkumar, Ujval; Antoun, Ghadi; Gandhi, Karan; Parmar, Gaganvir; Iqbal, Mohamed Ariff; Wong, Jacob; Richardson, Richard B; St-Pierre, Julie; Slack, Ruth S; Harper, Mary-Ellen.

Afiliação

Patten DA; University of Ottawa, Faculty of Medicine, Department of Biochemistry Microbiology and Immunology, Ottawa, ON, K1H 8M5, Canada; Canadian Nuclear Laboratories (CNL), Radiobiology and Health Branch, Chalk River Laboratories, Chalk River, ON K0J 1J0, Canada; Ottawa Institute of Systems Biology, Ottawa
McGuirk S; McGill University, Department of Biochemistry, Montreal, QC H3G 1Y6, Canada.
Anilkumar U; University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON K1H 8M5, Canada.
Antoun G; University of Ottawa, Faculty of Medicine, Department of Biochemistry Microbiology and Immunology, Ottawa, ON, K1H 8M5, Canada.
Gandhi K; University of Ottawa, Faculty of Medicine, Department of Biochemistry Microbiology and Immunology, Ottawa, ON, K1H 8M5, Canada.
Parmar G; University of Ottawa, Faculty of Medicine, Department of Biochemistry Microbiology and Immunology, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, Ottawa K1H 8M5, Canada.
Iqbal MA; University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON K1H 8M5, Canada.
Wong J; University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON K1H 8M5, Canada.
Richardson RB; Canadian Nuclear Laboratories (CNL), Radiobiology and Health Branch, Chalk River Laboratories, Chalk River, ON K0J 1J0, Canada; McGill Medical Physics Unit, Cedars Cancer Centre - Glen Site, Montreal, QC H4A 3J1, Canada.
St-Pierre J; University of Ottawa, Faculty of Medicine, Department of Biochemistry Microbiology and Immunology, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, Ottawa K1H 8M5, Canada; McGill University, Department of Biochemistry, Montreal, QC H3G 1Y6, Canada.
Slack RS; University of Ottawa, Faculty of Medicine, Department of Cellular and Molecular Medicine, Ottawa, ON K1H 8M5, Canada. Electronic address: rslack@uottawa.ca.
Harper ME; University of Ottawa, Faculty of Medicine, Department of Biochemistry Microbiology and Immunology, Ottawa, ON, K1H 8M5, Canada; Ottawa Institute of Systems Biology, Ottawa K1H 8M5, Canada. Electronic address: mharper@uottawa.ca.

Biochim Biophys Acta Mol Cell Res ; 1868(1): 118854, 2021 01.

Article em En | MEDLINE | ID: mdl-32926942

Assuntos

Antioxidantes/metabolismo; Glutationa/genética; Mitocôndrias/genética; Dinâmica Mitocondrial/genética; Trifosfato de Adenosina/metabolismo; Animais; Apoptose/genética; GTP Fosfo-Hidrolases/genética; Glutationa/biossíntese; Glicólise/genética; Humanos; Fusão de Membrana/genética; Camundongos; Mitocôndrias/metabolismo; Estresse Oxidativo/genética; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Glutathione; Metabolism; Mitochondrial dynamics; Mitochondrial fusion; Mitofusin 1 & 2; Optic atrophy 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dinâmica Mitocondrial / Glutationa / Mitocôndrias / Antioxidantes Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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