Comparison of the diagnostic quality of aspiration and core-biopsy needles for transjugular liver biopsy.
Dig Liver Dis
; 52(12): 1473-1479, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32928675
ABSTRACT
BACKGROUND:
Liver biopsy remains essential for the diagnostic work-up of patients with liver disease.AIMS:
To evaluate aspiration vs. core-biopsy needles for transjugular liver biopsy (TJLB) in patients undergoing hepatic venous pressure gradient (HVPG) measurements.METHODS:
84 patients undergoing TJLB between 06/2017 and 12/2018 were prospectively included. Liver biopsy specimens were systematically evaluated for quantitative and qualitative criteria such as number of portal tracts, sample length and fragmentation.RESULTS:
In direct comparison of paired TJLB specimens (n=35), core-biopsy samples were significantly longer (median 12 vs. 9mm, p=0.012), tended to contain more portal tracts (median 8 vs. 6, p=0.064) and were less fragmented (p<0.001), which resulted in better confidence for liver fibrosis assessment (p=0.035). However, a superior quality in terms of less fragmentation of core-biopsy specimens (p<0.05) was only confirmed in patients with HVPG ≥10mmHg or liver stiffness measurement >40kPa. In contrast, the aspiration needle provided significantly longer samples in patients with HVPG <10mmHg (median 21 vs. 12mm, p=0.007) or with liver stiffness measurement <20kPa (median 21 vs. 11mm, p=0.025).CONCLUSION:
In patients with HVPG ≥10mmHg, we recommend to performed TJLB using core-biopsy needles, while the aspiration needle provides high quality liver biopsy specimens in patients with HVPG <10mmHg.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Biópsia por Agulha
/
Pressão na Veia Porta
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Veias Jugulares
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Fígado
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Hepatopatias
Tipo de estudo:
Diagnostic_studies
/
Qualitative_research
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article