Stereo- and Regioselective Synthesis of O-Mannosyl Glycan Containing Matriglycan and a Part of Tandem Ribitol Phosphate.
J Org Chem
; 85(20): 12935-12946, 2020 10 16.
Article
em En
| MEDLINE
| ID: mdl-32930586
ABSTRACT
We herein successfully synthesized two pivotal structures of O-mannosyl glycan (1) the matriglycan-repeating tetrasaccharide Xylα1-3GlcAß1-3Xylα1-3GlcAß and (2) the link between matriglycan and a part of tandem ribitol phosphate, Xylα1-3GlcAß1-4Xylß1-4Rbo, in a regio- and stereocontrolled manner. The disaccharide unit with the α-linkage of xylose was obtained by adopting the conformational fixation of the xylopyranoside ring and a specific solvation system of diastereoselective solubility.
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MEDLINE
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En
Ano de publicação:
2020
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Article