Specialized regulatory T cells control venous blood clot resolution through SPARC.
Blood
; 137(11): 1517-1526, 2021 03 18.
Article
em En
| MEDLINE
| ID: mdl-32932520
ABSTRACT
The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg population that forms the matricellular acid- and cysteine-rich protein SPARC (secreted protein acidic and rich in cysteine) and show that SPARC enhances monocyte MMP activity and that SPARC+ Tregs are crucial for blood clot resorption. By comparing different treatment times, we define a therapeutic window of Treg expansion that accelerates clot resorption.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteonectina
/
Linfócitos T Reguladores
/
Trombose Venosa
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article