E3 ubiquitin ligase PARK2, an inhibitor of melanoma cell growth, is repressed by the oncogenic ERK1/2-ELK1 transcriptional axis.

Montagnani, Valentina; Maresca, Luisa; Apollo, Alessandro; Pepe, Sara; Carr, Ryan M; Fernandez-Zapico, Martin E; Stecca, Barbara

Montagnani, Valentina; Maresca, Luisa; Apollo, Alessandro; Pepe, Sara; Carr, Ryan M; Fernandez-Zapico, Martin E; Stecca, Barbara.

Afiliação

Montagnani V; Core Research Laboratory, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Maresca L; Core Research Laboratory, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Apollo A; Core Research Laboratory, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
Pepe S; Core Research Laboratory, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy; Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Carr RM; Division of Oncology Research, Department of Oncology, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota USA.
Fernandez-Zapico ME; Division of Oncology Research, Department of Oncology, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, Minnesota USA.
Stecca B; Core Research Laboratory, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. Electronic address: b.stecca@ispro.toscana.it.

J Biol Chem ; 295(47): 16058-16071, 2020 11 20.

Article em En | MEDLINE | ID: mdl-32938713

Assuntos

Sistema de Sinalização das MAP Quinases; Melanoma/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Proteínas Elk-1 do Domínio ets/metabolismo; Substituição de Aminoácidos; Linhagem Celular Tumoral; GTP Fosfo-Hidrolases/genética; GTP Fosfo-Hidrolases/metabolismo; Células HEK293; Humanos; Melanoma/genética; Melanoma/patologia; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Mutação de Sentido Incorreto; Proteínas Proto-Oncogênicas B-raf/genética; Proteínas Proto-Oncogênicas B-raf/metabolismo; Ubiquitina-Proteína Ligases/genética; Proteínas Elk-1 do Domínio ets/genética

Palavras-chave

ChIP; ERK; MAPK; chromatin immunoprecipitation; extracellular signal-regulated kinase; gene regulation; melanoma; mitogen-activated protein kinase; parkin; transcription factor; tumor suppressor gene

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema de Sinalização das MAP Quinases / Ubiquitina-Proteína Ligases / Proteínas Elk-1 do Domínio ets / Melanoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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