Dose-dependent efficacy of vaccination against K. pneumoniae in high and low antibody responder lines of mice.
Immunol Lett
; 14(4): 335-9, 1987 Apr.
Article
em En
| MEDLINE
| ID: mdl-3294582
Innate and acquired resistance to Klebsiella pneumoniae infection were investigated in high (HI) and low (LI) antibody responder lines of mice. The two lines were very susceptible to infection since even small inoculum doses of a virulent strain provoked a 100% mortality within a few days. However the mean survival time was significantly longer in LI than in HI. (HI X LI) F1 hybrids were more resistant than both parental lines. Immunization with heat killed K. pneumoniae was able to confer full protection on the mice in the two lines. However there was a large difference in the number of killed bacteria required to induce the protective effect in HI and in LI mice. The dose-effect relationship for protection correlated with that of antibody production. The protective role of antibodies was confirmed by the survival of HI and LI mice, when antibodies were passively given prior to lethal challenge. The results are in agreement with the fact already demonstrated, that the defect of LI mice in antibody responsiveness is a quantitative one. Therefore a satisfactory immune protection against K. pneumoniae could be obtained in LI mice by adapting the vaccination procedure.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por Klebsiella
/
Vacinas Bacterianas
/
Anticorpos Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article