First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters.
J Med Chem
; 63(20): 11548-11572, 2020 10 22.
Article
em En
| MEDLINE
| ID: mdl-32946232
ABSTRACT
The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT), and synthetic CAY10583 (CAY) have been recently described to accelerate wound healing by enhanced keratinocyte migration and indirect stimulation of fibroblast activity in diabetic rats. CAY represents a very valuable starting point for the development of novel wound-healing promoters. In this work, the first structure-activity relationship study for CAY scaffold-based BLT2 agonists is presented. The newly prepared derivatives showed promising in vitro wound-healing activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Queratinócitos
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Receptores do Leucotrieno B4
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Desenvolvimento de Medicamentos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article