Polyhalogenation of Isoflavonoids by the Termite-Associated Actinomadura sp. RB99.
J Nat Prod
; 83(10): 3102-3110, 2020 10 23.
Article
em En
| MEDLINE
| ID: mdl-32946237
ABSTRACT
Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Isópteros
/
Actinomadura
/
Isoflavonas
/
Antibacterianos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article