A Metabolic Bottleneck for Stem Cell Transformation.
Cell
; 182(6): 1377-1378, 2020 09 17.
Article
em En
| MEDLINE
| ID: mdl-32946778
Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization remain unknown. In this issue of Cell, Bonnay et al. identify enhanced electron transport chain activity as a critical determinant of this process, establishing metabolic reprogramming as limiting for tumor initiation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Células-Tronco Neurais
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article