PINK1-mediated mitophagy protects against hepatic ischemia/reperfusion injury by restraining NLRP3 inflammasome activation.

Xu, Ying; Tang, Yinbing; Lu, Jiawei; Zhang, Weiya; Zhu, Yan; Zhang, Shouliang; Ma, Gui; Jiang, Pengcheng; Zhang, Wenbo

Xu, Ying; Tang, Yinbing; Lu, Jiawei; Zhang, Weiya; Zhu, Yan; Zhang, Shouliang; Ma, Gui; Jiang, Pengcheng; Zhang, Wenbo.

Afiliação

Xu Y; Department of Laboratory Center, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Tang Y; Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Lu J; Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Zhang W; Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Zhu Y; Department of Respiration, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Zhang S; Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Ma G; Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Jiang P; Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China. Electronic address: pc_jsu@yahoo.com.
Zhang W; Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China. Electronic address: wb.zhan@hotmail.com.

Free Radic Biol Med ; 160: 871-886, 2020 11 20.

Article em En | MEDLINE | ID: mdl-32947010

Assuntos

Inflamassomos; Mitofagia; Proteínas Quinases; Traumatismo por Reperfusão; Animais; Camundongos; Camundongos Endogâmicos C57BL; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Proteínas Quinases/genética; Traumatismo por Reperfusão/genética

Palavras-chave

Hepatic ischemia/reperfusion injury; Inflammasome; Mitophagy; NLRP3; PINK1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Traumatismo por Reperfusão / Inflamassomos / Mitofagia Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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