Blowing up Neural Repair for Stroke Recovery: Preclinical and Clinical Trial Considerations.
Stroke
; 51(10): 3169-3173, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32951539
ABSTRACT
The repair and recovery of the brain after stroke is a field that is emerging in its preclinical science and clinical trials. However, recent large, multicenter clinical trials have been negative, and conflicting results emerge on biological targets in preclinical studies. The coalescence of negative clinical translation and confusion in preclinical studies raises the suggestion that perhaps the field of stroke recovery faces a fate similar to stroke neuroprotection, with interesting science ultimately proving difficult to translate to the clinic. This review highlights improvements in 4 areas of the stroke neural repair field that should reorient the field toward successful clinical translation improvements in rodent genetic models of stroke recovery, consideration of the biological target in stroke recovery, stratification in clinical trials, and the use of appropriate clinical trial end points.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Recuperação de Função Fisiológica
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Acidente Vascular Cerebral
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Reabilitação do Acidente Vascular Cerebral
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Plasticidade Neuronal
Tipo de estudo:
Clinical_trials
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article