Nicotinic acid receptor agonists impair myocardial contractility by energy starvation.

Watson, William D; Timm, Kerstin N; Lewis, Andrew J; Miller, Jack J J; Emmanuel, Yaso; Clarke, Kieran; Neubauer, Stefan; Tyler, Damian J; Rider, Oliver J

Watson, William D; Timm, Kerstin N; Lewis, Andrew J; Miller, Jack J J; Emmanuel, Yaso; Clarke, Kieran; Neubauer, Stefan; Tyler, Damian J; Rider, Oliver J.

Afiliação

Watson WD; Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Timm KN; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Lewis AJ; Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Miller JJJ; Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Emmanuel Y; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Clarke K; Department of Physics, University of Oxford, Oxford, UK.
Neubauer S; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Tyler DJ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Rider OJ; Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.

FASEB J ; 34(11): 14878-14891, 2020 11.

Article em En | MEDLINE | ID: mdl-32954525

Assuntos

Metabolismo Energético; Coração/efeitos dos fármacos; Hipolipemiantes/farmacologia; Contração Miocárdica; Niacina/análogos & derivados; Pirazinas/farmacologia; Receptores Acoplados a Proteínas G/agonistas; Trifosfato de Adenosina/sangue; Adulto; Animais; Metabolismo dos Carboidratos; Humanos; Hipolipemiantes/administração & dosagem; Insulina/sangue; Masculino; Fosfocreatina/sangue; Pirazinas/administração & dosagem; Complexo Piruvato Desidrogenase/metabolismo; Ratos; Ratos Wistar

Palavras-chave

31P MR spectroscopy; cardiac metabolism; hyperpolarized 13C pyruvate; nicotinic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Receptores Acoplados a Proteínas G / Metabolismo Energético / Coração / Contração Miocárdica / Hipolipemiantes / Niacina Tipo de estudo: Observational_studies Limite: Adult / Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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