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Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain.
Grunewald, Susanne; Klug, Lillian R; Mühlenberg, Thomas; Lategahn, Jonas; Falkenhorst, Johanna; Town, Ajia; Ehrt, Christiane; Wardelmann, Eva; Hartmann, Wolfgang; Schildhaus, Hans-Ulrich; Treckmann, Juergen; Fletcher, Jonathan A; Jung, Sascha; Czodrowski, Paul; Miller, Stephen; Schmidt-Kittler, Oleg; Rauh, Daniel; Heinrich, Michael C; Bauer, Sebastian.
Afiliação
  • Grunewald S; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.
  • Klug LR; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Mühlenberg T; Portland VA Health Care System, Portland, Oregon; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon; and Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, Oregon.
  • Lategahn J; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.
  • Falkenhorst J; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Town A; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
  • Ehrt C; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Wardelmann E; Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.
  • Hartmann W; DKTK partner site Essen, German Cancer Consortium (DKTK), Heidelberg, Germany.
  • Schildhaus HU; Portland VA Health Care System, Portland, Oregon; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon; and Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, Oregon.
  • Treckmann J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
  • Fletcher JA; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), Dortmund, Germany.
  • Jung S; Gerhard-Domagk-Institute of Pathology, University of Münster Medical Center, Münster, Germany.
  • Czodrowski P; Gerhard-Domagk-Institute of Pathology, University of Münster Medical Center, Münster, Germany.
  • Miller S; Institute of Pathology, University Medical Center Essen, Essen, Germany.
  • Schmidt-Kittler O; Department of Visceral Surgery, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany.
  • Rauh D; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
  • Heinrich MC; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
  • Bauer S; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Dortmund, Germany.
Cancer Discov ; 11(1): 108-125, 2021 01.
Article em En | MEDLINE | ID: mdl-32972961
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tumores do Estroma Gastrointestinal Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tumores do Estroma Gastrointestinal Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article