High glucose alters the DNA methylation pattern of neurodevelopment associated genes in human neural progenitor cells in vitro.

Kandilya, Deepika; Shyamasundar, Sukanya; Singh, Dhiraj Kumar; Banik, Avijit; Hande, Manoor Prakash; Stünkel, Walter; Chong, Yap Seng; Dheen, S Thameem

Kandilya, Deepika; Shyamasundar, Sukanya; Singh, Dhiraj Kumar; Banik, Avijit; Hande, Manoor Prakash; Stünkel, Walter; Chong, Yap Seng; Dheen, S Thameem.

Afiliação

Kandilya D; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, MD10, Level 4, Singapore, 117594, Singapore.
Shyamasundar S; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, MD10, Level 4, Singapore, 117594, Singapore.
Singh DK; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, MD10, Level 4, Singapore, 117594, Singapore.
Banik A; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, MD10, Level 4, Singapore, 117594, Singapore.
Hande MP; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Stünkel W; Experimental Drug Development Centre, Agency for Science, Technology and Research, Singapore, Singapore.
Chong YS; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Dheen ST; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, 4 Medical Drive, MD10, Level 4, Singapore, 117594, Singapore. antstd@nus.edu.sg.

Sci Rep ; 10(1): 15676, 2020 09 24.

Article em En | MEDLINE | ID: mdl-32973238

Assuntos

Encéfalo/efeitos dos fármacos; Encéfalo/crescimento & desenvolvimento; Metilação de DNA/efeitos dos fármacos; Glucose/farmacologia; Células-Tronco Neurais/efeitos dos fármacos; Células-Tronco Neurais/metabolismo; Encéfalo/citologia; Relação Dose-Resposta a Droga; Epigênese Genética/efeitos dos fármacos; Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos; Genômica; Via de Sinalização Hippo; Humanos; Proteínas do Tecido Nervoso/metabolismo; Células-Tronco Neurais/citologia; Proteínas Serina-Treonina Quinases/metabolismo; Transdução de Sinais/efeitos dos fármacos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Metilação de DNA / Células-Tronco Neurais / Glucose Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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