Genetic Encoding of <i>para</i>-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions.

Qianzhu, Haocheng; Welegedara, Adarshi P; Williamson, Holly; McGrath, Amy E; Mahawaththa, Mithun C; Dixon, Nicholas E; Otting, Gottfried; Huber, Thomas

Genetic Encoding of para-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions.

Qianzhu, Haocheng; Welegedara, Adarshi P; Williamson, Holly; McGrath, Amy E; Mahawaththa, Mithun C; Dixon, Nicholas E; Otting, Gottfried; Huber, Thomas.

Afiliação

Qianzhu H; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Welegedara AP; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Williamson H; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
McGrath AE; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales 2522, Australia.
Mahawaththa MC; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Dixon NE; Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales 2522, Australia.
Otting G; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
Huber T; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia.

J Am Chem Soc ; 142(41): 17277-17281, 2020 10 14.

Article em En | MEDLINE | ID: mdl-32975937

Assuntos

Aminoacil-tRNA Sintetases/metabolismo; DNA Polimerase III/metabolismo; Fluorocarbonos/química; Fenilalanina/química; Aminoacil-tRNA Sintetases/genética; Ciclodextrinas/química; DNA Polimerase III/genética; Escherichia coli/enzimologia; Escherichia coli/genética; Flúor/química; Interações Hidrofóbicas e Hidrofílicas; Isomerases/metabolismo; Modelos Moleculares; Mutação; Ligação Proteica; Conformação Proteica; Propriedades de Superfície; Ubiquitina/química

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilalanina / DNA Polimerase III / Fluorocarbonos / Aminoacil-tRNA Sintetases Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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