Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells.
Biophys J
; 119(8): 1617-1629, 2020 10 20.
Article
em En
| MEDLINE
| ID: mdl-32976760
ABSTRACT
Migratory cells are known to adapt to environments that contain wide-ranging levels of chemoattractant. Although biochemical models of adaptation have been previously proposed, here, we discuss a different mechanism based on mechanosensing, in which the interaction between biochemical signaling and cell tension facilitates adaptation. We describe and analyze a model of mechanochemical-based adaptation coupling a mechanics-based physical model of cell tension coupled with the wave-pinning reaction-diffusion model for Rac GTPase activity. The mathematical analysis of this model, simulations of a simplified one-dimensional cell geometry, and two-dimensional finite element simulations of deforming cells reveal that as a cell protrudes under the influence of high stimulation levels, tension-mediated inhibition of Rac signaling causes the cell to polarize even when initially overstimulated. Specifically, tension-mediated inhibition of Rac activation, which has been experimentally observed in recent years, facilitates this adaptation by countering the high levels of environmental stimulation. These results demonstrate how tension-related mechanosensing may provide an alternative (and potentially complementary) mechanism for cell adaptation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polaridade Celular
/
Modelos Biológicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article