Intravenous Chlorpromazine as Potentially Useful Treatment for Chronic Headache Disorders.
Headache
; 60(10): 2530-2536, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32979239
ABSTRACT
OBJECTIVE:
The aim of this study was to describe a group of patients with chronic headache disorders (CH) and medication overuse headache (MOH) treated with intravenous chlorpromazine (IVC). We hypothesized that IVC is an effective and safe addition to well-known treatment strategies for CH and MOH management.INTRODUCTION:
Up to 4% of the general population could experience CH. Most cases occur in women, in association with MOH. To date, evidence to support different treatment strategies is lacking. Although IVC is frequently used in the emergency room (ER), documentation on its use as supportive treatment for CH and for withdrawal management of MOH is poor.METHODS:
A retrospective cohort of patients hospitalized to receive treatment for CH in a specialized neurological center in Argentina was analyzed.RESULTS:
A total of 35 CH patients were included. Of the 35 patients, 33 (94%) patients also presented MOH. Patients reported only minor side effects to IVC administration (mainly drowsiness and symptomatic hypotension). Three months after inpatient treatment, the number of ER visits made by these patients decreased from an average of 2.8 in the 3 months prior to hospitalization to 0.7 after it (72%, P = .009). Headache frequency decreased in 20/34 (59%) patients during the same time period. Pain levels had dropped from a mean of 8 points at admission (in the scale of 1-10) to 2 points at discharge. In the first 3 months of follow-up, the average number of days per month in which patients experienced headache decreased from 28.9 to 15.4 days (53.3%, P < .0001).CONCLUSION:
In this particular group of inpatients, there were no significant safety issues with IVC administration and the study might suggest that the efficacy of IVC as an add-on treatment for CH and MOH.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Clorpromazina
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Avaliação de Resultados em Cuidados de Saúde
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Antagonistas de Dopamina
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Transtornos da Cefaleia
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Transtornos da Cefaleia Secundários
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article