Intralysosomal lipid in long-term maintenance transplant atherosclerosis.
Arch Pathol Lab Med
; 101(9): 474-77, 1977 Sep.
Article
em En
| MEDLINE
| ID: mdl-329801
Intralysosomal accumulation of lipid has been implicated as an important mechanism in the pathogenesis of atherosclerosis. Although atherosclerosis develops frequently in organ transplants maintained on a long-term basis, to our knowledge no studies to date have demonstrated the intracellular localization of the lipid in this setting. Light and electron microscopic study of a renal artery branch from a transplanted kidney maintained for 3 1/2 years demonstrates that the lipid is sequestered within intimal smooth muscle cell lysosomes. The features of the atherosclerotic plaque in long-term transplantation appear to be identical to spontaneous lesions or those induced experimentally.
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Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
/
Artéria Renal
/
Transplante de Rim
/
Lipídeos
/
Lisossomos
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article