An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease.

Nativio, Raffaella; Lan, Yemin; Donahue, Greg; Sidoli, Simone; Berson, Amit; Srinivasan, Ananth R; Shcherbakova, Oksana; Amlie-Wolf, Alexandre; Nie, Ji; Cui, Xiaolong; He, Chuan; Wang, Li-San; Garcia, Benjamin A; Trojanowski, John Q; Bonini, Nancy M; Berger, Shelley L

Nativio, Raffaella; Lan, Yemin; Donahue, Greg; Sidoli, Simone; Berson, Amit; Srinivasan, Ananth R; Shcherbakova, Oksana; Amlie-Wolf, Alexandre; Nie, Ji; Cui, Xiaolong; He, Chuan; Wang, Li-San; Garcia, Benjamin A; Trojanowski, John Q; Bonini, Nancy M; Berger, Shelley L.

Afiliação

Nativio R; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lan Y; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Donahue G; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sidoli S; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Berson A; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Srinivasan AR; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shcherbakova O; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Amlie-Wolf A; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Nie J; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Cui X; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
He C; Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Wang LS; Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Garcia BA; Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA.
Trojanowski JQ; Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA.
Bonini NM; Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA.
Berger SL; Department of Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Nat Genet ; 52(10): 1024-1035, 2020 10.

Article em En | MEDLINE | ID: mdl-32989324

Assuntos

Doença de Alzheimer/genética; Agregação Patológica de Proteínas/genética; Proteoma/genética; Transcriptoma/genética; Acetilação; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/genética; Cromatina/genética; Epigenoma/genética; Histona Acetiltransferases/genética; Código das Histonas/genética; Histonas/genética; Humanos; Fragmentos de Peptídeos/genética; Agregação Patológica de Proteínas/patologia; Transdução de Sinais/genética; Ativação Transcricional/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteoma / Doença de Alzheimer / Transcriptoma / Agregação Patológica de Proteínas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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