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Homocysteinemia is Associated with the Presence of Microbleeds in Cognitively Impaired Patients.
Yoo, Jun Sang; Ryu, Chang-Hwan; Kim, Young Seo; Kim, Hee-Jin; Bushnell, Cheryl D; Kim, Hyun Young.
Afiliação
  • Yoo JS; Department of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
  • Ryu CH; Department of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
  • Kim YS; Department of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea. Electronic address: kimys1@hanyang.ac.kr.
  • Kim HJ; Department of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
  • Bushnell CD; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
  • Kim HY; Department of Neurology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
J Stroke Cerebrovasc Dis ; 29(12): 105302, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32992197
BACKGROUND & OBJECTIVE: Homocysteine is possibly associated with cerebral small vessel diseases such as leukoaraiosis, silent brain infarction and cerebral microbleeds, which are in turn associated with cognitive dysfunction. We aimed to examine the relationships between cerebral microbleeds (CMBs) and plasma total homocysteine (tHcy) level, methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cognitive function. METHODS: A total of 819 patients with memory disturbance who visited a dementia clinic consecutively were included in this study. We retrospectively collected demographic, clinical and laboratory data including tHcy level, MTHFR C677T polymorphism and Mini-Mental State Examination (MMSE). All patients underwent brain MRI including fluid attenuated inversion recovery (FLAIR) image and T2*-weighed gradient-echo (GRE) image. Logistic regression analysis was performed to test the association between risk factors and the presence of microbleeds. RESULTS: One hundred and sixty-one (19.7%) patients had CMBs, of whom 88 (54.7%) had CMBs in the lobar region. CMBs were more common in older hypertensive male patients with hyperhomocysteinemia. In multivariable analysis, plasma tHcy remained an independent predictor of the presence of CMBs after adjusting other confounders (OR: 1.035, 95% CI: 1.009-1.062, p = 0.009). Higher plasma tHcy level was also associated with number of CMBs, TT MTHFR genotype, and lower MMSE scores. CONCLUSIONS: Elevated plasma tHcy level is related to high prevalence of CMBs and cognitive dysfunction. Lowering plasma tHcy could be helpful in cognitively impaired patients who have CMBs or the MTHFR TT genotype.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Hiper-Homocisteinemia / Disfunção Cognitiva / Homocisteína Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemorragia Cerebral / Hiper-Homocisteinemia / Disfunção Cognitiva / Homocisteína Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article