Atypical Porcine Pestivirus Circulation and Molecular Evolution within an Affected Swine Herd.
Viruses
; 12(10)2020 09 25.
Article
em En
| MEDLINE
| ID: mdl-32992946
ABSTRACT
Atypical porcine pestivirus (APPV) is a single-stranded RNA virus from the family Flaviviridae, which is linked to congenital tremor (CT) type A-II in newborn piglets. Here, we retrospectively investigated the molecular evolution of APPV on an affected herd between 2013 and 2019. Monitoring was done at regular intervals, and the same genotype of APPV was found during the entire study period, suggesting no introductions from outside the farm. The nucleotide substitutions over time did not show substantial amino acid variation in the structural glycoproteins. Furthermore, the evolution of the virus showed mainly purifying selection, and no positive selection. The limited pressure on the virus to change at immune-dominant regions suggested that the immune pressure at the farm might be low. In conclusion, farms can have circulation of APPV for years, and massive testing and removal of infected animals are not sufficient to clear the virus from affected farms.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Suínos
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Infecções por Pestivirus
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Pestivirus
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Evolução Molecular
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article