Methylated Xanthones from the Rootlets of <i>Metaxya rostrata</i> Display Cytotoxic Activity in Colorectal Cancer Cells.

Mittermair, Eva; Kählig, Hanspeter; Tahir, Ammar; Rindler, Stefanie; Hudec, Xenia; Schueffl, Hemma; Heffeter, Petra; Marian, Brigitte; Krenn, Liselotte

Methylated Xanthones from the Rootlets of Metaxya rostrata Display Cytotoxic Activity in Colorectal Cancer Cells.

Mittermair, Eva; Kählig, Hanspeter; Tahir, Ammar; Rindler, Stefanie; Hudec, Xenia; Schueffl, Hemma; Heffeter, Petra; Marian, Brigitte; Krenn, Liselotte.

Afiliação

Mittermair E; Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Kählig H; Institute of Cancer Research, Department of Medicine I, and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.
Tahir A; Department of Organic Chemistry, University of Vienna, Währingerstraße 38, 1090 Vienna, Austria.
Rindler S; Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Hudec X; Department of Pharmacognosy, University of Vienna, Althanstraße 14, 1090 Vienna, Austria.
Schueffl H; Institute of Cancer Research, Department of Medicine I, and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.
Heffeter P; Institute of Cancer Research, Department of Medicine I, and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.
Marian B; Institute of Cancer Research, Department of Medicine I, and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.
Krenn L; Institute of Cancer Research, Department of Medicine I, and Comprehensive Cancer Center, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

Molecules ; 25(19)2020 Sep 28.

Article em En | MEDLINE | ID: mdl-32998226

Assuntos

Neoplasias Colorretais/patologia; Gleiquênias/química; Raízes de Plantas/química; Xantonas/farmacologia; Espectroscopia de Ressonância Magnética Nuclear de Carbono-13; Caspases/metabolismo; Proteínas de Ciclo Celular/metabolismo; Morte Celular/efeitos dos fármacos; Linhagem Celular Tumoral; DNA Topoisomerases Tipo I/metabolismo; Humanos; Metilação; Espectroscopia de Prótons por Ressonância Magnética; Inibidores da Topoisomerase/farmacologia; Xantonas/química

Palavras-chave

2-deprenyl-5-O-methyl-7-hydroxy-rhee-diaxanthone B; 2-deprenyl-5-O-methyl-7-methoxy-rheediaxanthone B; 2-deprenyl-6-O-methyl-7-hydroxy-rheediaxanthone B; 2-deprenyl-7-methoxy-rheediaxanthone B; Metaxya rostrata; metaxyaceae

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Raízes de Plantas / Gleiquênias / Xantonas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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