Universal Qualification of Near Ultraviolet Circular Dichroism Spectroscopy: Method Performance Parameters and Limits of Detection for Structural Differences.

Machalek, Nikola S; Li, Cynthia; Barton, Chris; Yan, Gang; Arthur, Kelly K

Machalek, Nikola S; Li, Cynthia; Barton, Chris; Yan, Gang; Arthur, Kelly K.

Afiliação

Machalek NS; KBI Biopharma, Inc, 1450 Infinite Drive, Louisville, CO 80027, USA; Takeda Pharmaceutical Co. Ltd, 95 Hayden Avenue, Lexington, MA 02421, USA. Electronic address: nmachalek@kbibiopharma.com.
Li C; KBI Biopharma, Inc, 1450 Infinite Drive, Louisville, CO 80027, USA; Takeda Pharmaceutical Co. Ltd, 95 Hayden Avenue, Lexington, MA 02421, USA.
Barton C; KBI Biopharma, Inc, 1450 Infinite Drive, Louisville, CO 80027, USA; Takeda Pharmaceutical Co. Ltd, 95 Hayden Avenue, Lexington, MA 02421, USA.
Yan G; KBI Biopharma, Inc, 1450 Infinite Drive, Louisville, CO 80027, USA; Takeda Pharmaceutical Co. Ltd, 95 Hayden Avenue, Lexington, MA 02421, USA.
Arthur KK; KBI Biopharma, Inc, 1450 Infinite Drive, Louisville, CO 80027, USA; Takeda Pharmaceutical Co. Ltd, 95 Hayden Avenue, Lexington, MA 02421, USA.

J Pharm Sci ; 109(12): 3728-3733, 2020 12.

Article em En | MEDLINE | ID: mdl-33002469

Assuntos

Dicroísmo Circular; Projetos de Pesquisa; Limite de Detecção

Palavras-chave

Analytical biochemistry; Circular dichroism; Detection threshold; Proteins; Spectroscopy; Tertiary structure; Weighted spectral difference

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Projetos de Pesquisa / Dicroísmo Circular Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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