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The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis.
Arena, Chiara; Gado, Francesca; Di Cesare Mannelli, Lorenzo; Cervetto, Chiara; Carpi, Sara; Reynoso-Moreno, Ines; Polini, Beatrice; Vallini, Erika; Chicca, Stefano; Lucarini, Elena; Bertini, Simone; D'Andrea, Felicia; Digiacomo, Maria; Poli, Giulio; Tuccinardi, Tiziano; Macchia, Marco; Gertsch, Jürg; Marcoli, Manuela; Nieri, Paola; Ghelardini, Carla; Chicca, Andrea; Manera, Clementina.
Afiliação
  • Arena C; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy; NCCR-TransCure, Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012, Bern, Switzerland.
  • Gado F; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Di Cesare Mannelli L; Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, 50139, Florence, Italy.
  • Cervetto C; Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, 16126, Genova, Italy.
  • Carpi S; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Reynoso-Moreno I; NCCR-TransCure, Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012, Bern, Switzerland.
  • Polini B; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Vallini E; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy; NCCR-TransCure, Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012, Bern, Switzerland.
  • Chicca S; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy; NCCR-TransCure, Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012, Bern, Switzerland.
  • Lucarini E; Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, 50139, Florence, Italy.
  • Bertini S; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • D'Andrea F; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Digiacomo M; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Poli G; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Tuccinardi T; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Macchia M; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Gertsch J; NCCR-TransCure, Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012, Bern, Switzerland.
  • Marcoli M; Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, 16126, Genova, Italy.
  • Nieri P; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Ghelardini C; Department of Neuroscience, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, 50139, Florence, Italy.
  • Chicca A; NCCR-TransCure, Institute of Biochemistry and Molecular Medicine, University of Bern, CH-3012, Bern, Switzerland. Electronic address: andrea.chicca@ibmm.unibe.ch.
  • Manera C; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy. Electronic address: clementina.manera@farm.unipi.it.
Eur J Med Chem ; 208: 112858, 2020 Dec 15.
Article em En | MEDLINE | ID: mdl-33002735
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridonas / Analgésicos / Anti-Inflamatórios / Esclerose Múltipla Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridonas / Analgésicos / Anti-Inflamatórios / Esclerose Múltipla Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article