Building better polymerases: Engineering the replication of expanded genetic alphabets.

Ouaray, Zahra; Benner, Steven A; Georgiadis, Millie M; Richards, Nigel G J

Ouaray, Zahra; Benner, Steven A; Georgiadis, Millie M; Richards, Nigel G J.

Afiliação

Ouaray Z; School of Chemistry, Cardiff University, Park Place, Cardiff, United Kingdom.
Benner SA; Foundation for Applied Molecular Evolution, Alachua, Florida, USA.
Georgiadis MM; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: mgeorgia@iu.edu.
Richards NGJ; School of Chemistry, Cardiff University, Park Place, Cardiff, United Kingdom; Foundation for Applied Molecular Evolution, Alachua, Florida, USA. Electronic address: RichardsN14@cardiff.ac.uk.

J Biol Chem ; 295(50): 17046-17059, 2020 12 11.

Article em En | MEDLINE | ID: mdl-33004440

Assuntos

Replicação do DNA; DNA/biossíntese; Engenharia de Proteínas; Taq Polimerase; DNA/genética; Taq Polimerase/química; Taq Polimerase/genética

Palavras-chave

DNA polymerase; X-ray crystallography; biotechnology; computer modeling; directed evolution; enzyme mechanism; enzyme structure; expanded genetic alphabets; molecular dynamics; nucleoside/nucleotide analogue; protein-DNA interaction; synthetic biology

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Engenharia de Proteínas / Taq Polimerase / Replicação do DNA Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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